A study conducted in the university of Boston, USA in the year 2010 showed that increase in the age leads to biological changes which reduces joint capabilities to cope with adversity such as oxidative damage, poor proprioception, muscle weakness and thinning of cartilage. Whereas a study in England, UK shows that reduced BMD and use of oral contraceptive pills may be associated with knee OA. In 2005, a study named ‘A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis’ shows that females are more prone to knee OA than men. which require heavy weight lifting, squatting and kneeling have high chances to develop knee OA. Especially the jobs such as farmers, dock workers, mine workers etc. According to global burden of disease published in the year 2000 shows that some specific jobs and occupations which involve physical labor have increased risk to develop OA of knee. Change in the lifestyle leads to several types of diseases in which knee OA is leading amongst all.
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